2Abant İzzet Baysal Üniversitesi Tıp Fakültesi, Üroloji Anabilim Dalı, Bolu OBJECTIVES
Sarcomatoid differentiation has been reported in 8% of whole renal cell carcinoma (RCC) and is associated with bad prognosis, increased risk of metastasis.
METHODS
Patients with RCC between April 2008 and July 2011 were
analyzed, retrospectively.
RESULTS
There were 209 RCC patients. Rate of sarcomatoid differentiation
was 3.3% (n=7). Median age was 53 (min 45-max 69).
Patients were men. Histological subtype was clear cell carcinoma
in 3 patients (42.9%) and chromophobic in 1 patient
(14.3%). Five of the patients (71.4%) were stage 4, one of
them (14.3%) was stage 3, and 1 of them (14.3%) stage 2.
Interferon treatment was administered to 2 patients (28.6%)
and antracyline based chemotherapy to 2 patients (28.6%)
as systemic therapies. In median 1 month follow-up (min:1 -
max:78) 4 of 7 patients (57.5%) were dead.
CONCLUSION
In the early stages of RCC, main treatment modality is surgery.
Gemcitabine-adriamycin, are used for sarcomatoid differentiated
RCC patients despite low response rates.