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İstanbul Üniversitesi, Cerrahpaşa Tıp Fakültesi, Pediatrik Hematoloji Onkoloji BD., İstanbul The current paper aimed to evaluate the characteristics of Wilms tumour and the results of combined modality treatment obtained in our centre, in Turkey. From January 1978 to December 1996, 106 patients with Wilms Tumour (WT) were diagnosed. Of these 106 patients, 61were male and 45 were female (M/F=1.35); the median age at diagnosis was 39 months. The most frequent presenting findings included palpable mass (95%), abdominal pain (31 %) and macroscopic hematuria (6%). The distribution of the 106 patients according to clinical stage was stage I 10%, stage II 42%, stage III 35%, stage IV %9 and stage V 4%. Histologically, 102 of the cases could be evaluated favourable histology (FH) was diagnosed in 88.2% and unfavourable histology (UF) in 11.8% of the patients. A left nephrectomy was performed in 50 cases, a right nephrectomy in 42 patients, 4 cases underwent partial nephrectomy and 10 cases only biopsies. Ninety-one patients were treated according to NWTS and 8 patients according to SIOP protocols. Seven of the patients were followed in other centres. The EFS and overall survival rates at 2 years are 74.2% and 79.5% respectively. The EFS and overall survival rates at 5 years are 72,4% and 76.6% respectively. Keywords :