Does Diabetes Mellitus Increase Radiotherapy/ Chemoradiotherapy Acute Toxicities?
Eda ERDIŞ1,Birsen YÜCEL1
1Department of Radiation Oncology, Sivas Cumhuriyet University, Sivas-Türkiye DOI : 10.5505/tjo.2023.4072 OBJECTIVE
The effect of DM on the acute toxicities of RT/CRT was investigated.

1892 patients were evaluated retrospectively. Acute toxicities were evaluated weekly during Radiotherapy (RT)/Cardiac resynchronization therapy (CRT) and follow ups were performed after 1 and 3 months according to Radiation Therapy Oncology Group criteria. The patients were divided into those without diabetes mellitus (DM) (Group 1, n=1557 82%) and patients with DM (Group 2, n=335 18%).

There was a difference between the groups in terms of gender (p<0.001), median age (p<0.001), diagnosis (p=0.023), adjuvant (p=0.023), and concurrent (p=0.047) chemotherapy. Grade 3-4 skin (p=0.001), Grade 1-2 lower gis (lower gastrointestinal system [GIS], p<0.001), and Grade 1-2 gus toxicities (GUS, p=0.012) were all observed more in Group 2; the time for which skin toxicity occurred was earlier in Group 2 (p=0.002). Grade 1-2 white blood cells (p=0.027) and Grade 1-2 hemoglobin toxicities (p=0.033) were observed more in Group 1. Hypertension coexisted in 206 patients (61% of the DM group), and blood glucose was not regulated in 256 patients (76%). In DM patients, the toxicity of grade 3-4 skin (p<0.001) and grade 1-2 lower GIS (<0.001) was higher if hypertension coexisted, while grade 1-2 lower GIS (p=0.029) was higher in DM patients whose blood glucose was not regulated.

In this study, it was observed that DM negatively affected acute toxicity of RT/CRT, and having hypertension and lack of regulation of blood glucose contributed to this negativity. Keywords : Acute toxicity; diabetes mellitus; radiotherapy