2Department of Anesthesiology and Reanimation, Kayseri Training and Research Hospital, Kayseri-Turkey
3Department of Pathology, Kayseri Training and Research Hospital, Kayseri-Turkey
4Department of Radiation Oncology, Erciyes University Faculty of Medicine, Kayseri-Turkey OBJECTIVE
The aim of the present study was to investigate early histopathological changes in small intestinal tissue caused by radiotherapy (RT) applications with varying dose rates in rats.
METHODS
Thirty rats were divided into 3 groups. The first and second groups were irradiated at 300 MU/min and 600
MU/min, respectively. The third was a control group. On day 7 following RT application, small intestine tissue
samples were obtained.
RESULTS
Mucosal thickness was significantly lower in the 300 MU/min group, compared to the other groups,
and thickness was significantly lower in the 600 MU/min group, compared to the control group. Villus
length was significantly decreased in the 300 MU/min group, compared to the other groups, and villus
width was significantly increased in the control group, compared to the other groups.
CONCLUSION
RT application with high dose may be less toxic for tissue with high risk for acute toxicity, such as that
of the small intestine.