TURKISH JOURNAL OF ONCOLOGY 2015 , Vol 30 , Num 4
Limited stage small cell lung cancer: Treatment results and prognostic factors
Halil Cumhur YILDIRIM, 1 Şefika Arzu ERGEN, 1 Elif Eda TİKEN, 1 Günel ZALOVA, 1 Hande TURNA,2 Didem Çolpan ÖKSÜZ,1 Fazilet Öner DİNÇBAŞ1
1İstanbul Üniversitesi Cerrahpaşa Tıp Fakültesi, Radyasyon Onkolojisi Anabilim Dalı, İstanbul
2İstanbul Üniversitesi Cerrahpaşa Tıp Fakültesi, Medikal Onkoloji Bilim Dalı, İstanbul OBJECTIVES
To evaluate the treatment results and prognostic factors in patients with limited stage small cell lung cancer patients, retrospectively.

METHODS
Fifty-two patients with limited stage small cell lung cancer treated between 2005 and 2012, in our hospital were retrospectively evaluated.

RESULTS
The 2-year overall survival and disease free survival rates were 48% and 15%. On univariate analysis T1 tumor (p=.012), concomittant chemoradiotherapy (p=.023), start of radiotherapy within the 3 months after diagnosis (p=.026) and prophylactic cranial irradiation (p=.025) significantly improved disease free survival rate. Concomittant chemoradiotherapy (p<.001), early radiotherapy (p<.001) and prophylactic cranial irradiaton (p=.001) significantly affected overall survival rate. On multivariate analysis, only prophylactic cranial irradiation was found to be an independent factor affecting overall survival rate (p=.003).

CONCLUSION
Our results were consistent with the literature even though small sample size. Prophylactic cranial irradiation was determined the only independent factor that affects overall survival. Keywords : Prophylactic cranial radiotherapy; limited stage small cell lung cancer; thoracic radiotherapy