2 İ.Ü. Cerrahpaşa Tıp Fakültesi, Radyasyon Onkolojisi Anabilim Dalı, İstanbul
3 İ.Ü. Cerrahpaşa Tıp Fakültesi, Biyokimya Anabilim Dalı, İstanbul OBJECTIVES
To evaluate the role of some parameters of dose volume histograms (DVH) and plasma TGF-β levels in predicting radiation pneumonitis in non-small cell lung cancer (NSCLC) patients.
METHODS
Fifteen NSCLC patients treated with 3D conformal radiotherapy
were included in the study. Radiotherapy dose was a
median 60 Gy. Mean lung dose (MLD), V20 and V30 were calculated
from both ipsilateral and contralateral lung DVH.
TGF-β levels were studied with ELISA.
RESULTS
Median follow-up was 16 months (range 10-55). Radiation
pneumonitis was diagnosed in three patients (6, 9, 12
months). Dose parameters of ipsi- and contralateral lungs
revealed that higher MLD, V20, V30 values in contralateral
lung were statistically significant for pneumonitis (p<0.005).
There was no statistical correlation between plasma TGF-β
levels and radiation pneumonitis.
CONCLUSION
In this study, high doses in contralateral lung (MLD, V20,
V30), when compared with ipsilateral lung, were shown as
risk factors for developing radiation pneumonitis. TGF-β levels
seem non-predictive for pneumonitis in the short term.