TURKISH JOURNAL OF ONCOLOGY 2006 , Vol 21 , Num 1
Curative radiotherapy in early stage glottic laryngeal carcinoma
Mustafa ESASSOLAK, Senem DUBOVA, Serra KAMER, Barbaros AYDIN
Ege Üniversitesi Tıp Fakültesi Radyasyon Onkolojisi Anabilim Dalı OBJECTIVES
To evaluate the prognostic factors and the treatment results in early stage glottic laryngeal carcinoma patients treated with radiation therapy.

METHODS
The records of 83 patients (80 males; 3 females; mean age 62 years; range 40 to 85 years) treated with radical radiotherapy at Ege University Medical School Department of Radiation Oncology during January 1995-December 2004 were studied retrospectively.

RESULTS
Twenty-nine patients had (34.9%) T1a, 29 patients had (34.9%) T1b and 25 patients had (30.1%) T2 stage disease. During a median follow-up of 56 months, 13 patients had failures. Five year local control rates were 90.5% in T1 and 73.2% in T2 patients. Locoregional control rates were 89% in T1 and 70.5% in T2 patients. Treatment interruption more than 5 days was noted as a prognostic factor affecting local and locoregional control. Five year disease specific survival rates were 94% in T1 and 79% in T2 patients, T stage and radiotherapy interruption more than 5 days were noted as prognostic factors affecting disease specific survival.

CONCLUSION
Curative radiotherapy is an effective treatment modality in early stage glottic laryngeal cancer. Keywords : Carcinoma; laryngeal neoplasms/mortality/pathology/ therapy; laryngectomy/methods; neoplasm staging; prognosis; radiotherapy dosage; radiotherapy, adjuvant; randomized controlled trials; survival analysis