TURKISH JOURNAL OF ONCOLOGY 2000 , Vol 15 , Num 1
MOLECULAR ANALYSIS OF T(14;18) TRANSLOCATION IN NON-HODGKIN'S LYMPHOMA
HÜLYA YAZICI, SEVİL BAVBEK, MELİH AKTAN, GÜLTEN AKTUĞLU, NEJAT DALAY
İ.Ü. Onkoloji Enstitüsü, Temel Onkoloji AD., İstanbul The chromosomal translocation t(14;18) in non-Hodgkin's lymphoma patiens can be determined by using bcl-2 and immunoglobulin heavy chain specific probes. In this study 44 patients were analyzed for t(14;18) translocation and in 9 patients bcl-2 and in 18 patients immunoglobulin chain rearrengements wede found. We concluded that molecular analysis of peripheral blood samples of malignant lymphoma patients is an effective method for determining translocations. Keywords :