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¹Department of Radiation Oncology, Hacettepe University Faculty of Medicine, Ankara-Türkiye DOI : 10.5505/tjo.2023.3846 Surface-guided radiation therapy (SGRT) has gained wide popularity across radiation oncology community due to its non-radiographic characteristic and real-time motion monitoring capability. Nevertheless, it has not yet gained its full potential in routine clinical practice. Implementing SGRT system into the clinical practice requires not only the definition of steps in clinical workflow, but also establishment of the comprehensive quality assurance (QA) program including commissioning, acceptance and periodic QA test to facilitate a safe, and efficient use of SGRT system in clinical settings. This review focuses on the latest recommendation of American Association of Physicists in Medicine and European Society for Radiotherapy and Oncology guidelines about the implementation of comprehensive QA program for SGRT system. Keywords : Patient positioning; radiotherapy; surface guidance