2Department of Neurosurgery, Istanbul University-Cerrahpaşa, Cerrahpaşa Faculty of Medicine, İstanbul-Türkiye
3Department of Neurosurgery, Kırıkkale Provincial Health Directorate Yüksek İhtisas Hospital, Kırıkkale-Türkiye
4Department of Public Health, Istanbul University-Cerrahpasa, Cerrahpasa Faculty of Medicine, İstanbul-Türkiye
5Department of Pathology, Istanbul University-Cerrahpaşa, Cerrahpaşa Faculty of Medicine, İstanbul-Türkiye DOI : 10.5505/tjo.2022.3710 OBJECTIVE
The objective of the study was to evaluate the outcomes of central neurocytoma treatments.
METHODS
Between 2003 and 2019, 23 post-operative patients with central neurocytoma were included in the study.
According to the World Health Organization (WHO) 2021 classification, 14 patients were classified as
atypical neurocytoma. Gross total resection was performed in 12 patients whereas subtotal resection
(STR) was performed in ten patients and eight patients had residual disease. In total, 13 patients received
radiotherapy (RT), nine of whom were irradiated postoperatively, and four patients were irradiated after
relapse. Recurrence and progression-free survival (PFS) of each subgroup were presented.
RESULTS
The median follow-up was 59 months (15?262 months). The 5-year overall survival (OS) was 89.3%
and PFS was 83.4%. During follow-up in total three patients died; two patients had disease progressionrelated
death, and one patient died because of his comorbidities. Comparing the outcome of RT group
and the observation group; there was no recurrence in the radiotherapy group, but three recurrences or
progression were detected in the observation arm. There was no statistical significance (p=0.257) due
to the low number of patients in this subgroup. Patients with extraventricular tumors received postoperative
radiotherapy; however, patients had recurrences and died due to disease progression. Furthermore,
there was no statistical significance (p=1.00) when the operation type was evaluated. In terms of
histopathology, recurrence or progression was observed in two patients with typical CN and one patient
with atypical histology, which was not statistically significant (p=0.247).
CONCLUSION
All treatment modalities were applied in our cohort, but due to the small number of patients, the significance
of any modality could not be demonstrated. However, the prognosis of the patients with extraventricular
pathology was very poor and two patients died due to the disease.