2Department of Medical Documentation and Secretarial Program, Van Yuzuncu Yil University, Vocational School of High of Health Services, Van-Turkey DOI : 10.5505/tjo.2022.3453 OBJECTIVE
In this study, we aimed to investigate the oxidant-antioxidant capacity in bladder cancer according to invasion and degree.
METHODS
Forty-six patients with bladder cancer and 50 healthy volunteers were included in the study. After 12 h
of fasting, 4cc of blood venous blood was taken from these patients. Then, after centrifugation at 5000
rpms for 10 min, the serum portion of the study was completed. The activities of arylesterase (ARE),
paraoxanase-1 (PON-1), glutathione reductase (GR), glutathione-S transferase, and protein carbonyl
(PC) in serum were measured spectrophotometrically.
RESULTS
Antioxidant parameters in the serum of patients with bladder tumors were found lower than control
group (p=0.001). In addition, PC was found to be higher in the bladder cancer group than in the control
group (p=0.001); on the other hand, ARE, PON-1, and GR levels were found to be lower in both highgrade
tumors and invasive tumors (p≤0.05).
CONCLUSION
Oxidative stress is effective in the development and progression of bladder tumors.