2Department of Radiation Oncology, University of Health Sciences, Dr. Suat Seren Chest Diseases and Surgery Training and Research Hospital, İzmir-Turkey
3Department of Radiation Oncology, Istanbul University-Cerrahpaşa, Cerrahpasa Faculty of Medicine, Istanbul-Turkey
4Department of Radiation Oncology, Baskent University, Adana Dr. Turgut Noyan Application and Research Center, Adana-Turkey
5Department of Radiation Oncology, Trakya University, Edirne-Turkey
6Department of Radiation Oncology, Ankara University, Ankara-Turkey DOI : 10.5505/tjo.2021.3420 OBJECTIVE
We aimed to evaluate the role of consolidative thoracic radiotherapy (TRT) in patients with extensivestage small cell lung cancer (ES-SCLC).
METHODS
The clinical data for 151 patients with the diagnosis of ES-SCLC treated with consolidative TRT from six
different hospitals from Turkey analyzed.
RESULTS
The median age of the patients was 61 years (range 36-83 years). The median dose of radiotherapy (RT)
was 45 Gy (range: 30-66 Gy) applied in median 25 fractions (range 10-34 fractions). For 151 assessable
patients, the median survival time (MST) was 14 months (range: 12.6-15.3). The patients who has complete
response and partial response had 16 months, and 14 months of MST. In multivariate analyses prophylactic
cranial irradiation (PCI) (p=0.011), female gender (p=0.017), and comorbidity (p=0.006) were
found as significant parameters associated with survival. The MSTs were 12 months in patients without
comorbidity, and 16 months for the patients with at least one comorbid disease. The patients who received
PCI had improved MSTs when compared the ones without PCI (16 months vs. 12 months). There was a
trend towards improved overall survival times in patients who received EQD2 ≥47 Gy RT doses (p=0.08).
CONCLUSION
Female gender, use of PCI, and unavailability of comorbid disease were associated with improved survival
in ES-SLCL patients. There was a trend towards overall survival times in patients who received ≥47
Gy EQD2 doses; however, we believe that this statistical insignificance was related to our limited patient
numbers.