2Department of Medical Oncology, Manisa Celal Bayar University, Manisa-Turkey DOI : 10.5505/tjo.2021.2794 OBJECTIVE
In this study, we aim to determine which treatment is more appropriate in castration-resistant chemotherapy- naive patients. Therefore, docetaxel and agents active in the androgen pathway (abiraterone and enzalutamide) were compared retrospectively in patients progressing on androgen deprivation therapy.
METHODS
The study was designed as a retrospective and multicenter study. Patients from five centers in Turkey
were included in the study. The primary endpoint of the study was overall survival (OS) and the secondary
endpoint was progression-free survival.
RESULTS
Median OS of the docetaxel group was 18.66 months, it was 16.26 months in the hormonal treatment
group. There was no statistically significant difference between the groups (p=0.311). Median progressionfree
survival of the chemotherapy group was 5.6 months, while it was 9 months in the hormonal therapy
group. There was statistically significant difference between the groups (p=0.024).
CONCLUSION
There was statistical difference in progression-free survival in favor of hormonal therapies in our study. The
difference did not reflect on OS and there was no difference between hormonal therapies and docetaxel.
Heterogeneity in the selection of patients is considered to lead to this result; however, larger randomized
controlled studies are needed to determine the most appropriate treatment in these patients.