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¹Department of Radiation Oncology, Hacettepe University Medical School, Ankara-Turkey DOI : 10.5505/tjo.2019.2137 The rate of loco-regional recurrence and secondary primary tumors is high in patients with head and neck cancer (HNC). Although surgery is very effective in the management of these patients, total resection is rarely possible due to anatomic and functional constraints. In patients not amenable to surgery, chemoradiotherapy plays a major role and stereotactic body radiotherapy (SBRT) is the treatment of choice based on its advantage of high therapeutic ratio. Recent advances in immunotherapeutic agents also provide promising results in many tumor sites and may have advantages in the treatment of recurrent HNC. Concurrent use of these agents with SBRT is still being investigated. Keywords : Head and neck cancer; immunotherapy; radiotherapy; recurrent; stereotactic body radiotherapy